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Updates

74 cases; 23 deaths

10 April 2020


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Weekly update two -- 4th April 2020

Weekly update one -- 28th Feb 2020

COVID-Hep data summary

16:15:43 GMT, 10 Apr 2020
Please note that data are presented after only automated filtering, may include inconsistencies, and may change with time. We hope that this early summary will be of interest to those involved with liver patients and we hope to expand the granularity of the dataset with time. These small numbers of unselected cases cannot yet be recommended to guide clinical decisions and we recognise that the dataset is likely to be biased towards those hospitalised and with more significant disease outcomes.
CLD = chronic liver disease; CPT = Child-Pugh-Turcot score; IPPV = invasive positive-pressure ventilation; ITU = intensive therapy/care unit; NIV = non-invasive ventilation.

Contributors (with thanks)

Country n %
Belgium 5 6.8
France 3 4.1
Germany 1 1.4
Italy 6 8.1
Lithuania 1 1.4
Nigeria 1 1.4
Philippines 2 2.7
Spain 15 20.3
Switzerland 1 1.4
Thailand 1 1.4
Turkey 2 2.7
United Kingdom 32 43.2
Unknown 4 5.4

Overall

Liver disease n %
Cirrhosis 44 59.5
Other CLD 19 25.7
Transplant 11 14.9

Total deaths: 23 of 74 (31.1%)


Cirrhosis patients

Hospitalised: 42 of 44 (95.5%)

Cirrhotic Cases NIV ITU IPPV Died
Yes 44 6 (13.6%) 7 (15.9%) 6 (13.6%) 19 (43.2%)

By age group

10-year age group Cases NIV ITU IPPV Died
20- 1 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%)
40- 6 0 (0.0%) 0 (0.0%) 0 (0.0%) 3 (50.0%)
50- 10 2 (20.0%) 4 (40.0%) 3 (30.0%) 5 (50.0%)
60- 11 2 (18.2%) 1 (9.1%) 1 (9.1%) 4 (36.4%)
70- 12 2 (16.7%) 2 (16.7%) 2 (16.7%) 6 (50.0%)
80- 3 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (33.3%)
. 1 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%)


By Child-Pugh-Turcot stage

CPT Cases NIV ITU IPPV Died
A 13 1 (7.7%) 1 (7.7%) 2 (15.4%) 4 (30.8%)
B 16 2 (12.5%) 3 (18.8%) 3 (18.8%) 7 (43.8%)
C 12 2 (16.7%) 2 (16.7%) 1 (8.3%) 7 (58.3%)
Unknown 3 1 (33.3%) 1 (33.3%) 0 (0.0%) 1 (33.3%)

By cirrhosis aetiology

Aetiology Cases NIV ITU IPPV Died
AIH 1 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%)
Alcohol 13 2 (15.4%) 3 (23.1%) 2 (15.4%) 8 (61.5%)
Alcohol AIH 1 0 (0.0%) 0 (0.0%) 1 (100.0%) 0 (0.0%)
HBV 5 0 (0.0%) 1 (20.0%) 1 (20.0%) 1 (20.0%)
HCV 4 2 (50.0%) 1 (25.0%) 1 (25.0%) 3 (75.0%)
NASH 14 1 (7.1%) 1 (7.1%) 1 (7.1%) 5 (35.7%)
NASH Alcohol 2 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (50.0%)
NASH HCV 2 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (50.0%)
Other 1 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%)
. 1 1 (100.0%) 1 (100.0%) 0 (0.0%) 0 (0.0%)

By sex

Sex Cases NIV ITU IPPV Died
Female 12 2 (16.7%) 1 (8.3%) 1 (8.3%) 6 (50.0%)
Male 32 4 (12.5%) 6 (18.8%) 5 (15.6%) 13 (40.6%)

Decompensation

Cirrhotic Cases Ascites SBP Encephalopathy Variceal bleeding
Yes 44 15 (34.1%) 4 (9.1%) 10 (22.7%) 1 (2.3%)

Deaths among cirrhotic patients

Death 10-year age group Sex Aetiology CPT
1 60- Female Alcohol C
2 40- Female Alcohol Unknown
3 50- Male Alcohol C
4 70- Male NASH A
5 50- Male Alcohol C
6 70- Male Alcohol A
7 40- Male Alcohol C
8 50- Female NASH Alcohol B
9 40- Male HBV B
10 60- Male NASH HCV A
11 70- Male Alcohol C
12 80- Male HCV B
13 70- Male Alcohol B
14 50- Male NASH C
15 70- Female NASH B
16 70- Male NASH A
17 50- Male HCV B
18 60- Female HCV C
19 60- Female NASH B

Transplant patients

Only hospitalised patients included

Liver transplant Cases NIV ITU IPPV Died
Yes 11 3 (27.3%) 4 (36.4%) 1 (9.1%) 3 (27.3%)

Non-cirrhotic chronic liver disease patients

Only hospitalised patients included

Disease type Cases NIV ITU IPPV Died
Other CLD 19 6 (31.6%) 3 (15.8%) 2 (10.5%) 1 (5.3%)
8 April 2020

From today, we will begin to publish updates here in tabular format with more detail to follow with time. Previous updates here.